In this project, we propose to harness the antimicrobial and anti-inflammatory properties of ultraviolet-A (UVA) light to manipulate the intestinal microbiome and reduce inflammation in ulcerative colitis (UC) patients. Clinical trials for therapeutics in UC typically exclude patients with distal colitis/proctitis, and most patients do not achieve remission, even with optimized dosing of biologic therapy […]
The project will use mouse models of colitis to investigate the effects of TP-317 (Resolvin E1 magnesium lysinate) in blood, feces and intestinal tissue on key biomarkers that are involved in IBD pathophysiology and that Resolvin E1 has been shown to regulate in prior experiments. Key biomarkers of interest include (a) cytokines such as G-CSF, […]
