Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis, is a condition where the immune system mistakenly attacks the intestine, leading to chronic inflammation and bowel damage. One unique feature of IBD is the growth of new lymphatic vessels—tiny tubes responsible for draining fluids and immune cells to maintain balance in the body. However, in IBD, even with the formation of new lymphatic vessels, inflammation persists, suggesting that these vessels may not function properly.
Our recent findings reveal a specialized drainage system in the colon that follows specific structures called colonic folds. These folds degrade during colitis, disrupting the drainage system and contributing to inflammation. Additionally, we found that lymphatic vessels can adopt different structural states—either tightly sealed or more open—which can affect how well they transport fluids and immune cells.
We aim to understand how these lymphatic changes influence inflammation and immune responses in IBD. By studying the growth of lymphatic vessels and how their structures affect immune cell movement, we hope to uncover new ways to reduce inflammation and restore gut health. This research may lead to new treatments for people living with IBD by targeting lymphatic vessels to improve their function.
