The impact of dietary protein and fiber content on intestinal permeability and inflammation in moderate ulcerative colitis and healthy control.

Precise manipulation of diet and gut microbiota is a novel and non-invasive therapy for IBD which is of great interest to patients. Enteral nutrition provides a clear example of a dietary intervention improving clinical outcomes such as mucosal healing. However, previous studies in IBD have altered several different dietary components at once making it challenging to identify specific dietary factors with quantifiable, causal roles in IBD. Identifying these dietary ingredients that influence disease will allow us to compose a broader range of precise and clinically effective diets for IBD with better patient tolerance and adherence than enteral nutrition. In animal models, we screened over 30 defined diets to identify that protein and fiber in combination influence gut leakiness and inflammation. We will profile the effect of these diets on the mucosal immune system and leaky gut in healthy individuals and patients with moderate ulcerative colitis