Grants Archive - Page 157 of 180 - Kenneth Rainin Foundation

A new ensemble work instigated by Jess Curtis in collaboration with a diverse ensemble of Blind, Low Vision and sighted artists and consultants, which will examine cultural and phenomenological experiences of darkness and light. Into the Dark addresses the physical, subconscious and literal effects of Western thought’s binary mobilization of darkness and light in societal […]

There is a critical need for non-invasive tests of Crohn’s disease activity to effectively guide diagnosis and therapy. Changes in the gut bacteria both reflect and contribute to inflammation in Crohn’s disease; however, current diagnostic test including invasive endoscopy or imaging procedures do not provide functional insight into the contribution to the underlying pathogenesis. Here, […]

Patients with IBD most commonly suffer from diarrhea. However, some IBD subjects also experience bouts of constipation as well. We propose that viral infections that humans acquire through insect bites (mosquitos and ticks) can infect cells that innervate the intestines and control bowel movements. We found that the immune system recognizes these infected cells and […]

Crohn’s disease and ulcerative colitis are part of the group called inflammatory bowel disease (IBD), a medical condition where the immune system is causing severe intestinal and colonic inflammation leading to severe complications. Former therapies rely on suppressing the immune system but modern treatments, so-called biological treatments, are blocking certain steps in disease progression or […]

Eicosanoids are signaling molecules that contribute to both the development and resolution of inflammation. Inflammasomes are immune sensors that help to trigger immune responses to infection. Tuft cells are specialized cells of the intestinal lining that are important during infection with parasitic worms. Eicosanoids and inflammasomes have been separately implicated in IBD, although the underlying […]

Inflammatory bowel disease (IBD) causes significant human morbidity. A new area of research is to investigate gene regulation from unconventional portions of the genome, such as the newly identified long noncoding RNAs (lncRNAs). These new players have been implicated in many cellular processes. However, their role in inflammatory disease such as IBD has yet to […]