Crohn’s disease and ulcerative colitis are part of the group called inflammatory bowel disease (IBD), a medical condition where the immune system is causing severe intestinal and colonic inflammation leading to severe complications. Former therapies rely on suppressing the immune system but modern treatments, so-called biological treatments, are blocking certain steps in disease progression or […]
Eicosanoids are signaling molecules that contribute to both the development and resolution of inflammation. Inflammasomes are immune sensors that help to trigger immune responses to infection. Tuft cells are specialized cells of the intestinal lining that are important during infection with parasitic worms. Eicosanoids and inflammasomes have been separately implicated in IBD, although the underlying […]
Although there are many drugs available for the treatment of IBD, most patients do not respond long-term to any one drug. One possible reason is that the condition we call “IBD” likely represents many distinct diseases, rather than simply just ulcerative colitis and Crohn’s disease, and each subtype may require a different treatment. Here we […]
Inflammatory bowel disease (IBD) causes significant human morbidity. A new area of research is to investigate gene regulation from unconventional portions of the genome, such as the newly identified long noncoding RNAs (lncRNAs). These new players have been implicated in many cellular processes. However, their role in inflammatory disease such as IBD has yet to […]
Crohn’s disease and ulcerative colitis are part of the group called inflammatory bowel disease (IBD), a medical condition where the immune system is causing severe intestinal and colonic inflammation leading to severe complications. Former therapies rely on suppressing the immune system but modern treatments, so-called biological treatments, are blocking certain steps in disease progression or […]
Eicosanoids are signaling molecules that contribute to both the development and resolution of inflammation. Inflammasomes are immune sensors that help to trigger immune responses to infection. Tuft cells are specialized cells of the intestinal lining that are important during infection with parasitic worms. Eicosanoids and inflammasomes have been separately implicated in IBD, although the underlying […]
The cause of Inflammatory Bowel Disease (IBD) is unknown, but intestinal bacteria—involved in the production of molecules that impact health—are widely accepted to play a key role. A significant proportion of IBD patients with pouches (surgically created rectums after the diseased colon is removed) continue to have inflammation similar to their previous disease, whereas non-IBD […]
The intestines are home to a community of not only bacteria, but also fungi, which are involved in several immune-mediated inflammatory diseases, including IBD. It is unknown how fungi appear in the intestine and whether they are part of the intestinal microflora early in life. In this project, we will explore whether gut fungi can […]
According to the Montreal classification, ulcerative colitis (UC) disease scope varies from how much of the colon is affected, with lesser colon involvement called proctitis (E1) and extensive disease called pancolitis (E3). These differing extents impact rates of hospitalization, chance of colectomy, and cancer risk. When the extent of UC is limited (E1 or E2) […]
The cause of Inflammatory Bowel Disease (IBD) is unknown, but intestinal bacteria—involved in the production of molecules that impact health—are widely accepted to play a key role. A significant proportion of IBD patients with pouches (surgically created rectums after the diseased colon is removed) continue to have inflammation similar to their previous disease, whereas non-IBD […]
