Grants Archive - Page 165 of 187 - Kenneth Rainin Foundation

The role of IBD in the fungal microbiota transmission from pregnant women to the offspring.

The intestines are home to a community of not only bacteria, but also fungi, which are involved in several immune-mediated inflammatory diseases, including IBD. It is unknown how fungi appear in the intestine and whether they are part of the intestinal microflora early in life. In this project, we will explore whether gut fungi can […]

Toward identifying the unique pathology that explains Ulcerative Colitis distribution.

According to the Montreal classification, ulcerative colitis (UC) disease scope varies from how much of the colon is affected, with lesser colon involvement called proctitis (E1) and extensive disease called pancolitis (E3). These differing extents impact rates of hospitalization, chance of colectomy, and cancer risk. When the extent of UC is limited (E1 or E2) […]

Experimental and Clinical Studies of a Novel Antimicrobial Peptide Regulator of Fungal Commensalism in Health and IBD.

Identifying Critical Cellular Interactions for the Reversal of Inflammatory Bowel Disease.

Induction of Therapeutic Regulatory T cells by Parasite Products.

Label-free digital pathology and spatially resolved transcriptomics for the identification of novel biomarkers and therapeutic targets in inflammatory bowel diseases.

There is still no medical cure for inflammatory bowel diseases (IBD) and the clinical management is challenging. In particular, differentiating between Crohn’s disease (CD) and ulcerative colitis (UC) and predicting the clinical course or the response to therapy is difficult. In this study, we aim to characterize tissue samples from IBD and control patients with […]

Human and experimental animal studies to identify mechanisms governing lymph transport in Crohn’s disease.

Lymphatic vessels are specialized vessels that transport immune cells and fat out of the gut to maintain health. Surgeons treating Crohn’s disease decades ago argued that impaired lymphatic flow may be a key problem in the disease. However, only recently have tools emerged to study lymphatic vessels in detail. We have data that lymph transport […]

A novel IAP antagonist strategy for the treatment of IBD.

Intestinal Bowel Diseases (IBD) affect millions of lives worldwide. However, therapeutic options for IBD treatment are limited. In this proposal, building upon our previous findings, we propose to examine an important protein called ARTS, which has never-before been studied in connection to IBD. We have found that ARTS is able to coordinate the cellular suicide […]

Mechanistic analysis of NOD2 interactions with commensal bacteria muropeptides in Crohn’s disease.

Targeting the septin cytoskeleton as a novel mechanistic approach to therapy of fibrostenosing Crohn’s disease.

More than half of Crohn’s disease (CD) patients develop excessive scar tissue leading to intestinal blockage, ultimately requiring surgery with removal of parts of the bowel. This process can repeat itself, often resulting in multiple surgeries. There are many therapies that treat gut inflammation, but even when gut inflammation is controlled excessive scar tissue still […]