According to the Montreal classification, ulcerative colitis (UC) disease scope varies from how much of the colon is affected, with lesser colon involvement called proctitis (E1) and extensive disease called pancolitis (E3). These differing extents impact rates of hospitalization, chance of colectomy, and cancer risk. When the extent of UC is limited (E1 or E2) […]
The cause of Inflammatory Bowel Disease (IBD) is unknown, but intestinal bacteria—involved in the production of molecules that impact health—are widely accepted to play a key role. A significant proportion of IBD patients with pouches (surgically created rectums after the diseased colon is removed) continue to have inflammation similar to their previous disease, whereas non-IBD […]
The intestines are home to a community of not only bacteria, but also fungi, which are involved in several immune-mediated inflammatory diseases, including IBD. It is unknown how fungi appear in the intestine and whether they are part of the intestinal microflora early in life. In this project, we will explore whether gut fungi can […]
According to the Montreal classification, ulcerative colitis (UC) disease scope varies from how much of the colon is affected, with lesser colon involvement called proctitis (E1) and extensive disease called pancolitis (E3). These differing extents impact rates of hospitalization, chance of colectomy, and cancer risk. When the extent of UC is limited (E1 or E2) […]
There is still no medical cure for inflammatory bowel diseases (IBD) and the clinical management is challenging. In particular, differentiating between Crohn’s disease (CD) and ulcerative colitis (UC) and predicting the clinical course or the response to therapy is difficult. In this study, we aim to characterize tissue samples from IBD and control patients with […]
Lymphatic vessels are specialized vessels that transport immune cells and fat out of the gut to maintain health. Surgeons treating Crohn’s disease decades ago argued that impaired lymphatic flow may be a key problem in the disease. However, only recently have tools emerged to study lymphatic vessels in detail. We have data that lymph transport […]
Intestinal Bowel Diseases (IBD) affect millions of lives worldwide. However, therapeutic options for IBD treatment are limited. In this proposal, building upon our previous findings, we propose to examine an important protein called ARTS, which has never-before been studied in connection to IBD. We have found that ARTS is able to coordinate the cellular suicide […]
