The goal of this collaborative proposal is to create a novel 120,000 peptide chip for use in the diagnosis, prognosis, and treatment of Crohn’s disease. The peptides will be both random and specific to gut bacterial proteins implicated in complicated Crohn’s disease. Patients with Crohn’s disease have a distinctive pattern of antibody binding to random […]

More than half of Crohn’s disease (CD) patients develop excessive scar tissue leading to intestinal blockage, ultimately requiring surgery with removal of parts of the bowel. This process can repeat itself, often resulting in multiple surgeries. There are many therapies that treat gut inflammation, but even when gut inflammation is controlled excessive scar tissue still […]