Thetis is developing TP-317 as a safe, oral therapy for treatment of ulcerative colitis and Crohn’s Disease. TP-317 is a novel derivative of Resolvin-E1, a molecule that is produced naturally by the body to regulate inflammation and promote healing. By delivering Resolvin-E1 to the small intestine and colon, TP-317 activates natural pathways to resolve inflammation […]
The project will use mouse models of colitis to investigate the effects of TP-317 (Resolvin E1 magnesium lysinate) in blood, feces and intestinal tissue on key biomarkers that are involved in IBD pathophysiology and that Resolvin E1 has been shown to regulate in prior experiments. Key biomarkers of interest include (a) cytokines such as G-CSF, […]
The study was an early phase clinical trial of Fecal Microbiota Transplant (FMT), delivered via different routes (colonoscopy and enema or oral capsules) for mild to moerate ulcerative colitis. Additionally, they investigated if pre-treatment with antibiotics prior to FMT has an impact on the outcome. 30 subjects were enrolled in the clinical trial. 20 subjects […]
The rapid advancement in scientific innovations could easily seem like fiction to the casual observer. Each day seems to give new examples of a future in which we have the capabilities to radically transform human life in a laboratory. Embodying these concepts and pushing the boundaries of science are themes central to a growing field […]
Crohn’s disease is an inflammatory bowel disease associated with significant morbidity. While the etiology is incompletely understood, alterations in intestinal microbiome composition and immune regulation play prominent roles in disease pathogenesis. Dietary therapies, including exclusive enteral nutrition, have been demonstrated to have favorable effects on disease activity but are limited by poor tolerability, high cost […]
Supports OUSD, Education for Change and Aspire schools to implement equitable and restorative practices through individual coaching and mindfulness training for leaders and educators.
Supports the 22-23 Literacy Liberator Fellowship, which provides literacy skills, leadership skills and support in onboarding as tutors—Literacy Liberators—in OUSD.
Supports the operations, media, and advocacy of the 23-24 Literacy Liberator Fellowship, which provides literacy skills, leadership skills and support in onboarding as tutors—Literacy Liberators—in OUSD.
Supports its evidence-based summer program, which continues to prevent summer learning loss for participating students, and OUSD has drastically increased its contribution to the cost.
Individualized literacy support for 250 unduplicated students at OUSD public and charter schools with twice weekly, 45-minute literacy tutoring sessions.
