Supports pooled funding to drive multilingual priorities supporting students, families and educators across three geographic areas of California, including Oakland.
Funds a percentage of educator and tutor training, coaching and tutor wages, and fully funds central leadership across five schools.
Supports the continuation of the Little Steps to College program in a community hub in Fruitvale.
Funds a percentage of educator and tutor training and coaching, tutor wages and central leadership across four schools.
Supports after-school literacy interventions, leader coaching, teacher planning and family engagement for one OUSD school and two charter schools in the Sobrante Park neighborhood.
Inflammatory Bowel Disease (IBD) comprises incurable chronic diseases of the gut which oscillate between periods of disease worsening (i.e. relapse) and relatively normal health (i.e. remission). Whilst current medicines often reduce this see-sawing problem, their effectiveness eventually wanes to the point where a large percentage of IBD patients still need hospitalisation and major surgery during […]
We have discovered a novel single-gene defect in patients with pediatric IBD, setting the stage for new molecular and cellular discoveries to dissect biology stemming from human disease. Here, we will pursue two aims that will open new doors by leveraging the strength of preclinical models to uncover mechanisms by which the gene we identified […]
Sorbitol is a sugar alcohol that is not absorbed very well in our bodies. It is usually broken down in the gut by a type of bacteria called Clostridia. When these bacteria are not there, sorbitol accumulates and that leads to increased osmotic stress for the cell lining our intestines. Our cells have many defense […]
The intestinal immune system must maintain a delicate balance between harmless bacteria in the gut and immunity against dangerous pathogens. Dysregulation of this balance can lead to Inflammatory Bowel Diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease. Many treatments for IBD focus on blocking inflammation and fail to repair damaged tissue and restore […]
The epithelial cells lining the intestine control responses to gut bacteria, limiting intestinal damage in Crohn’s disease. A critical gene in this pathway is DUOX2, which is up-regulated in response to bacteria, and helps maintain intestinal health. We discovered that Crohn’s disease patients who carry genetic variants in DUOX2 are more likely to progress to […]
