A dance/music/language collaborative project by Risa Jaroslow, Rinde Eckert, Margaret Jenkins, Jon Kinzel and Vicky Shick. All artists of several different disciplines, all fully “emerged,” all over 55, most over 70, “Unstill Life” is an experiment in shedding the director role and coming together as equal partners to investigate the changing body, beauty, endurance, loss […]
The first aim of this grant was to compare the motility results provided by the GutTracker Wireless Patch System with an existing FDA cleared measurement, the Medtronic SmartPill. GutTracker results are reported in terms of the frequencies and strengths of peaks in time-based frequency spectra. These were shown to be in concordance with spectral analysis […]
In this study, we discovered the efficacy and safety of the specific wavelength and bandwidth of ultraviolet-A (UVA) light as an antimicrobial modality. In vitro safety studies using a fiber optic UVA delivery system supported by the Kenneth Rainin Foundation showed that, under specific and monitored conditions, UVA can be safely applied even at close […]
In this project, we propose to harness the antimicrobial and anti-inflammatory properties of ultraviolet-A (UVA) light to manipulate the intestinal microbiome and reduce inflammation in ulcerative colitis (UC) patients. Clinical trials for therapeutics in UC typically exclude patients with distal colitis/proctitis, and most patients do not achieve remission, even with optimized dosing of biologic therapy […]
Early studies indicate that the specific carbohydrate diet (SCD) may improve clinical symptoms and inflammatory biomarkers, but there is not enough high-quality evidence to be sure. N-of-1 (or single-subject repeated cross-over) trials are an ideal method for addressing this important research question. By focusing on the effect of diet for a single individual, N-of-1 studies […]
There is a clear unmet need for ulcerative colitis (UC) patients – only a quarter of UC patients achieve remission with present therapies. Currently, there is no standardized way that studies are conducted for UC, and each study is doing things slightly different, which makes the results hard to compare and slows drug development. The […]
The aims of this grant project were to develop two basic ideas that were just past the proof-of-concept stage, into functional computer code to perform processing of the large raw datasets supplied by the GutTracker wireless patch system, intended to form the first steps in the future standard data analysis. The first step was a cleanup […]
Thetis is developing TP-317 as a safe, oral therapy for ulcerative colitis patients whose disease is incompletely controlled by first-line therapy that would be an alternative to aggressive immuno-suppressive therapies. TP-317 is a novel derivative of Resolvin-E1, a molecule that is produced naturally by the body to regulate inflammation and promote healing. By delivering Resolvin-E1 […]
Thetis is developing TP-317 as a safe, oral therapy for treatment of ulcerative colitis and Crohn’s Disease. TP-317 is a novel derivative of Resolvin-E1, a molecule that is produced naturally by the body to regulate inflammation and promote healing. By delivering Resolvin-E1 to the small intestine and colon, TP-317 activates natural pathways to resolve inflammation […]
The project will use mouse models of colitis to investigate the effects of TP-317 (Resolvin E1 magnesium lysinate) in blood, feces and intestinal tissue on key biomarkers that are involved in IBD pathophysiology and that Resolvin E1 has been shown to regulate in prior experiments. Key biomarkers of interest include (a) cytokines such as G-CSF, […]
