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Abstract or Project Description

Abstract or Project Description

To support the “Black Girls Do” arts, youth development and mentoring program.

Abstract or Project Description

General support for thought leadership, visioning, strategy and examples of a regenerative economy.

Abstract or Project Description

The Tanzania School Foundation Inc. is a nonprofit organization dedicated to providing educational opportunities for children in Tanzania. Through various programs and initiatives, the foundation works to improve access to quality education, infrastructure and resources in underserved communities, aiming to empower students and create brighter futures for them and their communities.

Abstract or Project Description

To sponsor Black Philanthropy Month 2020, including the Black Giving and Beyond Summit.

Abstract or Project Description

Theatre Bay Area is dedicated to promoting the arts for all, embodying values of community, inclusion and service while advocating for diversity, equity and inclusion. As the largest arts service organization of its kind, Theatre Bay Area provides extensive resources to support its members’ radical creativity, contributing to the vibrant cultural landscape of the region.

Abstract or Project Description

A historical exploration of the intersection of the Native American and Japanese American immigrant experiences. This new work draws upon Ojibwe, Potawatomi, and Comanche traditions, storytelling, and traditional Japanese Noh to underscore similarities in spirituality, folklore, generational trauma, and historical experiences of Indigenous American and immigrant cultures.

Abstract or Project Description

Thetis is developing TP-317 as a safe, oral therapy for treatment of ulcerative colitis and Crohn’s Disease. TP-317 is a novel derivative of Resolvin-E1, a molecule that is produced naturally by the body to regulate inflammation and promote healing. By delivering Resolvin-E1 to the small intestine and colon, TP-317 activates natural pathways to resolve inflammation and repair damaged tissue without suppressing the immune system. A previous KRF grant supported the development of a prototype oral capsule formulation of TP-317. The current grant proposal supports the manufacture of clinical trial material for early clinical development. The proposed grant is a supplement to the KRF off-cycle grant that Thetis received in August 2018, which funds the development of a TP-317 prototype oral formulation. In Aim #1, Thetis will synthesize and qualify drug substance under current good manufacturing practices (cGMP). In Aim #2, Thetis will manufacture cGMP drug product for early clinical studies utilizing the prototype being developed from the prior KRF grant. In Aim #3, Thetis will submit an investigational new drug (IND) application for initiation of Phase 1 clinical trials.

Abstract or Project Description

To hire a science writer to expedite writing up the results of The Justice Study, a research project by Dr. Rupa Marya at UCSF, to investigate the health outcomes in communities where there is police violence and no justice.

Abstract or Project Description

To administer The Rainin Fellowship.

Abstract or Project Description

For the Myeloma Immunotherapy Research Fund, to support basic and clinical scientists in developing novel cellular and immuno-therapies in multiple myeloma under the direction of Dr. Tom Martin and Dr. Jeff Wolf.

Abstract or Project Description

Although there are many drugs available for the treatment of IBD, most patients do not respond long-term to any one drug. One possible reason is that the condition we call “IBD” likely represents many distinct diseases, rather than simply just ulcerative colitis and Crohn’s disease, and each subtype may require a different treatment. Here we will address this problem by using a suite of state-of-the-art laboratory techniques that will allow us to study the genetic instructions (RNA) of thousands of individual cells sampled from the intestines of patients with IBD. Using bioinformatic methods, we will use this information to classify IBD into different diseases, which may help us to determine how best to treat each subtype. We also hope to discover new molecules that are involved in causing IBD, an important first step to developing new treatments for IBD

Abstract or Project Description

The gut microbiota is believed to play a critical role in inflammation in Crohn’s disease (CD). Adherent–invasive Escherichia coli (AIEC) often colonize the intestinal mucosa of CD patients. AIEC colonization may promote intestinal inflammation in CD patients. We have found that AIEC prefers to use the amino acid L-serine for growth in the inflamed gut. As dietary proteins are a major source of L-serine in the gut lumen, withholding L-serine from the diet prevents the growth of AIEC in the gut of mice. These facts suggest that a diet deprived of L-serine may alleviate CD symptoms by modulating the gut microbiota, in particular, the colonization by AIEC. In this project, we will validate the effect of dietary L-serine modification on the microbiome and disease outcomes by using a human microbiota–associated mouse model and studying CD patients

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To support housing for student interns participating in the Black Leadership Fellowship Program. Grant amendment 9/27/2022: To provide scholarships supporting the retention and persistence of BASE participants with demonstrated unmet financial need.

Abstract or Project Description

Urban Alchemy aim to raise the vibrations in urban spaces Ð and save the lives of those who exist on their streets. Advocating against defaulting to police intervention for issues related to poverty and desperation, they emphasize the need for alternative approaches to addressing trauma, addiction and mental illness.

Abstract or Project Description

A performance using sign language, film, dance, and folk/rock music to educate audiences on the experiences of Deaf refugees, the Deaf Diaspora, and their battles against audism and discrimination.

Abstract or Project Description

Explores the historic and systemic exploitation of female labor in the US/Mexico borderlands through new choreography centered in American tap, Zapateado Son Jarocho and Afro-Carribbean rythms and movement. Ghostly Labor_ tells the story of grassroots activism and perseverance of Chicana and Native workers, bringing to light the resilience, beauty, and humanity of some of the most vulnerable and unseen people in our society.

Abstract or Project Description

Lymphatic vessels are specialized vessels that transport immune cells and fat out of the gut to maintain health. Surgeons treating Crohn’s disease decades ago argued that impaired lymphatic flow may be a key problem in the disease. However, only recently have tools emerged to study lymphatic vessels in detail. We have data that lymph transport is impaired even in early Crohn’s disease. However, treatments targeting the cytokine TNF reverse the impaired transport. As investigators specializing in different lymphatic research areas, we will synergistically utilize human subjects’ studies with research in mice and rats to map in detail how terminal ileal inflammation alters lymph flow. We will also address whether a gut hormone called GIP that is overproduced in the setting of TNF neutralizing therapy accounts for how therapy against TNF restores lymph flow. If so, mimetics of the hormone may have utility in subjects unable to use therapeutics against TNF.