Using genetic approaches, the Guo lab seeks to understand and reprogram the molecular “language” of host-microbe interactions in health and disease for potential therapeutic applications.
The Goodman lab aims to dissect the mechanisms that commensal gut microbes use to compete, cooperate and antagonize each other in the gut and explore how microbiome variation impacts our response to pathogenic infection and medical drugs.
The Garrett lab focuses on mucosal immunology and the gut microbiota. They study intestinal inflammation in colitis and the tumor microenviroment in colorectal cancer, with a specific focus on the gut microbiota and immune system.
Dr. Alenghat’s lab investigates cell homeostasis in intestinal health and disease, searching for insight into pathways that mediate the host-microbiota relationship and how regulation affects innate immunity and chronic conditions like IBD.
Dr. Elson’s lab focuses on the regulation of mucosal immune responses, particularly the mucosal immune response to the microbiota, to define the cellular and molecular mechanisms that maintain mucosal immune homeostasis.
The Martens lab investigates the symbiotic microorganisms in the human gastrointestinal tract at multiple levels with the goal of using diet and gut microbial interventions to treat chronic conditions such as Inflammatory Bowel Disease.
Dr. Swanson’s research focuses on understanding the mechanisms of intestinal barrier homeostasis that drive IBD, and how environmental factors like circadian misalignment and alcohol impact intestinal barrier permeability.
The Cadwell Lab investigates how our immune system is regulated by diverse infectious agents. They aim to apply this knowledge towards treating inflammatory diseases through restoring a balanced relationship between microbes and the immune system.
The Bäumler lab has pioneered the study of microbial physiology in its natural context of a host-associated microbial community. An overarching theme of their research is that the host plays a key role in shaping its gut microbiota to be beneficial.
Dr. Barton’s group studies innate immunity with the goal of understanding strategies of pathogen recognition and self/non-self discrimination to reveal critical balance points with fundamental implications for our understanding of immunity.
