Grants Archive - Page 3 of 176 - Kenneth Rainin Foundation

The epithelial cells lining the intestine control responses to gut bacteria, limiting intestinal damage in Crohn’s disease. A critical gene in this pathway is DUOX2, which is up-regulated in response to bacteria, and helps maintain intestinal health. We discovered that Crohn’s disease patients who carry genetic variants in DUOX2 are more likely to progress to […]

Our gut is constantly exposed to environmental harms, such as bacteria and dietary products, among others. The epithelium layer of our intestinal tract, which is the most exposed to the external world, contains a variety of immune cells, which likely play an important role in patrolling and defending our intestine. However, how these cells protect […]

Colonization of the infant gut by commensal bacteria profoundly influences immune development and can thus have significant long-term consequences: promoting durable tolerance to environmental antigens or driving Inflammatory Bowel Disease (IBD). Despite the importance of this process for health, how immune responses to the microbiota are regulated during early life remain a significant gap in […]

The human gut microbiome has a profound impact on gut immunity in health and disease. Host-microbe interactions play a key role in Inflammatory Bowel Diseases (IBD), including Crohn’s disease and ulcerative colitis. Microbial-induced immune pathways are plausible targets for intervention in IBD. Protists are unicellular organisms that commonly inhabit the human gut. Presently, the most […]

Ulcerative colitis (UC) is characterized by non-resolving pathological inflammation leading to erosion of the colon tissue. Recent studies analyzing gene expression signatures in UC patients highlighted specific colonic fibroblast populations that may contribute to inflammation and disease progression. While these studies emphasize the proinflammatory function of activated intestinal fibroblasts, it is unknown whether subsets of […]

Patients with Inflammatory Bowel Disease (IBD) have dysfunctions in gut motility, the movement of muscles in the gastrointestinal tract. Currently, most available therapeutics developed to directly target the gut fail to stabilize symptoms, suggesting that dysfunctions in gut motility could arise from pathological changes occurring outside the gut. Intriguingly, gut motility problems also occur at […]

The bacteria in the human colon can influence gastrointestinal lining cells (intestinal epithelial cells (IECs)) and immune cells within the intestines and throughout the body. One way that bacteria do this is through their metabolites, the chemicals they produce. By influencing IECs and immune cells, gut bacterial metabolites affect resistance and susceptibility to Inflammatory Bowel […]