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Abstract or Project Description

Abstract or Project Description

The human intestine is home to trillions of bacteria of hundreds of different types, which are collectively referred to as the gut microbiota. Ideally, these microbes exist in a balanced state, where both microbe and man benefit from their presence. However, imbalances in the microbiota, which are referred to as ‘dysbiosis’, have been suggested to underlie the development of a variety of inflammatory diseases, including IBD. While there is broad consensus that microbiota composition in patients with IBD differs from healthy controls, it remains unknown whether this dysbiosis is a cause or effect of the imbalanced immune responses that underlie IBD development. Here, we propose to use a new model system to experimentally examine the effect of dysbiosis in patients with IBD on the gut immune system. These studies will reveal whether imbalances in the gut microbiota play a causal role in the immunological imbalances that trigger IBD development, and will reveal potential mechanisms by which we can correct dysbiosis to prevent or cure IBD in the future.

Abstract or Project Description

Inflammatory Bowel Disease (IBD) is associated with currently untreatable conditions such as fibrosis and strictures that arise as a consequence of aberrant wound healing. It is of utmost importance that we understand the biology of normal wound healing and discover why IBD is associated instead with abnormal wound healing. Immune cells called macrophages help sense damage and rebuild injured tissues. We have discovered that macrophages promote tissue repair when they sense that cells have died by a specific suicide mechanism called apoptosis. We propose that, if macrophages sense that cells have died by other means such as necroptosis, it is sensed as danger by sentinel macrophages and they respond by producing factors that cause fibrosis. We aim to identify the sensors that macrophages use to identify dead cells and hide the ones that sense danger and promote bad healing, while tricking the macrophages to use their apoptosis sensors that instruct good healing. Our studies have the potential to address a currently unmet need in IBD therapy.

Abstract or Project Description

The Rainin Foundation provided planning grants to the following organizations to develop proposals for network of services models and pilots serving individual artists and artist-led organizations. These research and design grants are part of the Foundation’s ongoing work to explore alternative pathways for artist support systems that unleash creativity, address systemic inequities and reduce administrative burdens that constrain the creative process.

Abstract or Project Description

The Young Musicians Choral Orchestra (YMCO) is dedicated to enriching the lives of talented, low-income students aged 9-18 across the Bay Area through high-quality musical training, academic support and personal guidance.

Abstract or Project Description

Youth Beat provides free digital media training to kids from some of the Bay AreaÕs lowest income neighborhoods. Their mission is to help inner-city kids get on a path that leads to success in college, career and life.

Abstract or Project Description

A mixed media project that will engage young people in six San Francisco and Oakland communities to tell stories about their neighborhoods. Audiences will travel by BART to experience these stories through live performance, audio and print.

Abstract or Project Description

Will invite three experimental, women-led theater companies to work with 3Girl Theatre Company’s (3GT) creative team to develop and present staged readings on-site at a San Francisco tech company. By connecting edgy young theater innovators with their counterparts in technology, 3GT hopes to spark new kinds of artistic collaboration and build audiences for new plays by women.

Abstract or Project Description

Uses Geologic Time as the basic unit of measurement in order to embody large-scale, planetary and galactic forces. Privileging non-human logics, the immersive performance will allow for expression of phenomena that are often perceived as invisible to become intelligible, actionable, and performative.

Abstract or Project Description

An interdisciplinary performance of Urban African culture created from narratives prompted by the question, Wey you dey? (Pidgin English for “Where were you?”), directed by Nkeiruka Oruche and Tossie Long.

Abstract or Project Description

Invites performing artists to study the exhibition of an artist working in another discipline, and to respond to that work as a live subject.

Abstract or Project Description

A meal in the streets of West Oakland that centers on the shared struggle, resilience, and healing remedies of people of color. This five hundred person public art project is the final culminating event in a series of community events called Remedies: From the Farm, To the Kitchen, To the Table, To the Streets.

Abstract or Project Description

Arts Industry Alliance is a non-profit organization focused on programs and initiatives of education, production and recognition. TEAM is a homegrown arts, music and cultural non-profit initiative dedicated to the production, promotion and organization of original programming, projects and events in the Exeter area.

Abstract or Project Description

To support SEEDS of Learning, an eight month professional development program for Transitional Kindergarten and Kindergarten teachers, that includes materials, classroom tutor resources and ongoing coaching support. Funding will support 18 classrooms. 

Abstract or Project Description

A multidisciplinary performance series of collaborative projects bridging LGBTQ+ performance artists, dancers and technologists, which will address important yet underrepresented local and national issues such as women’s and transgender rights and safety of queer bodies in the LGBTQ+ community.

Abstract or Project Description

BAICFFÕs mission is to present engaging, culturally diverse films and education programs for children and families.

Abstract or Project Description

Contribution to the endowment fund.

Abstract or Project Description

To fund a book access program that allows students to choose the books they are most excited to read (with level guidance from their teachers), and keep them for their home libraries.

Abstract or Project Description

To fund the pilot of a technology platform that will allow community volunteers, parents and other lay people to support students with one-on-one and small group instruction.

Abstract or Project Description

Camp Common Ground Oakland is a Bay Area summer camp for middle schoolers from different economic, racial and religious backgrounds.