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Abstract or Project Description

Abstract or Project Description

To support the East Bay Relief Fund for Individuals in the Arts.

Abstract or Project Description

Charlotte Maxwell Clinic is a 30-year-old nonprofit providing complementary, integrative therapies to low-income and underserved women with cancer.

Abstract or Project Description

To support the Deputy Director of Education role.

Abstract or Project Description

Curve magazine, launched in 1991 as Deneuve, has evolved into AmericaÕs leading lesbian magazine under the guidance of founder Franco Stevens. Ahead of its 30th anniversary, Franco reimagined Curve’s role, founding The Curve Foundation to empower and support the LGBTQ+ community through storytelling, leadership development and archival preservation, ensuring the continuity of LGBTQ+ women’s culture and history.

Abstract or Project Description

The PeopleÕs Conservatory empowers young artists, particularly from Black and Brown marginalized communities, to create meaningful art that addresses social issues, fostering cultural awareness and positive change. Through a curriculum rooted in ethnic and cultural studies, students develop their artistic voices and become leaders in their communities.

Abstract or Project Description

Abstract or Project Description

To continue educator retention and sustainability programs at seven elementary schools and within several leadership teams.

Abstract or Project Description

The Unquiet Professional is a organization committed to recognizing and honoring our nationÕs Gold Star & Surviving Families, Veterans and military families by providing rewarding and purposeful opportunities to heal from the wounds of war.

Abstract or Project Description

For general support and to provide support for the executive director transition.

Abstract or Project Description

The project will use mouse models of colitis to investigate the effects of TP-317 (Resolvin E1 magnesium lysinate) in blood, feces and intestinal tissue on key biomarkers that are involved in IBD pathophysiology and that Resolvin E1 has been shown to regulate in prior experiments. Key biomarkers of interest include (a) cytokines such as G-CSF, GM-CSF, IFN-γ, IL-10, IL-12p40, IL-12p70, IL-15, IL-17A, IL-8, IL-1β, IL-2, IL-23, IL-6, TGF-β1 and TNF-α; (b) intestinal alkaline phosphatase, a protein that plays a role in maintaining gut homeostasis and (c) Lipocalin-2 (LCN2), a marker of inflammation in feces. Unbiased RNA sequencing of tissue also will be conducted to identify novel biomarkers. Lastly, the study will evaluate the relationship between disease activity and biomarker response to identify potential biomarkers for clinical investigation.

Abstract or Project Description

To support essential financial, academic and personal services for former foster youth and other students impacted by the child-welfare system.

Abstract or Project Description

Support for the Basic Needs Center.

Abstract or Project Description

To support basic and clinical scientists in developing novel cellular and immuno-therapies in multiple myeloma under the direction of Dr. Tom Martin and Dr. Jeff Wolf.

Abstract or Project Description

The microbes that flourish within our guts are central to many aspects of human health. Which microbes are present can dictate susceptibility to a number of acute and chronic diseases, including IBD. This proposal will use a mouse model with a defined and stable set of bacteria to probe how mice interact with specific members of their microbiota in health and during disease. First, each microbe will be tested for its ability to elicit an immune response in healthy mice. Once we have established the baseline response in normal healthy mice, we will use chemicals to disrupt the gut lining to elicit an inflammatory response, or we will disrupt genes known to limit intestinal inflammation. We will then investigate how immune recognition of the microbiota changes under these altered conditions. This system will enable us to track responses to the microbiota with unprecedented precision and will provide clues regarding which microbes drive immune activation during dysregulated responses to the microbiota. Such studies will pave the way for future work aimed at manipulating responses to key members of the microbiota responsible for inflammatory diseases of the gut.

Abstract or Project Description

Diet is thought to be a major environmental factor contributing to inflammatory bowel disease (IBD) and represents a non-invasive path to improve this debilitating condition. To leverage diet to treat IBD the precise ways that dietary components influence development or healing of inflammation need to be determined. We discovered that different dietary protein sources have variable effects on intestinal inflammation and these effects are dependent on the community of microorganisms (microbiome) that inhabit the human colon. In particular, we discovered that soy protein promotes production of a beneficial metabolite called isobutyrate that reduces inflammation in a mouse model of IBD that we developed to mimic low fiber diet- and microbiome-driven inflammation. Isobutyrate is only produced by some bacteria and is derived from the dietary amino acid L-valine via at least two different metabolic pathways. Because soy protein specifically promotes isobutyrate, our model is that it is better at delivering L-valine-containing peptides to the colon after digestion, leading to bacterial isobutyrate production. The proposed experiments will uncover the specific component(s) of soy protein that promotes isobutyrate as well as the bacteria that produce this metabolite so that dietary protein can be optimized in the context of patients’ microbiomes to reduce inflammation.

Abstract or Project Description

The Black Achievement Success and Engagement (BASE) initiative at the University of San Francico provides a foundation for students to grow, learn, discover and thrive. By offering high-impact academic and extracurricular programs that center on the unique and yet varied experiences of students of African descent, BASE equips students with the knowledge, resources, skills and support necessary to turn their dreams into reality.

Abstract or Project Description

The Community Empowerment Activists (CEA) is a year-long community-engaged learning (CEL) program that prepares students as visionary organizers and movement workers by examining the historical and current contexts of systems of oppression and movements of resistance that raise consciousness and build People power using a transformative justice lens.