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Abstract or Project Description

Abstract or Project Description

Males and females with IBD differ in terms of incidence of disease, symptoms and response to treatments. The underlying reasons are largely unknown. Understanding why these sex differences exist could reveal why many patients develop IBD as they enter young adulthood. Sex hormones such as testosterone surge during adolescence and then circulate at very different levels in males and females. These hormones are powerful signaling molecules that regulate diverse aspects of physiology and may play a role in IBD. Clinical studies hint that testosterone signaling is protective in IBD, but it is largely unclear which cells this hormone signals to in the gut and how this signaling might influence intestinal inflammation. We have discovered that testosterone signals to an important population of nerve cells along the gut-brain axis, called nociceptors, that communicate information about the gut to the brain and regulate local immune responses. Using mice in which we can specifically disable testosterone signaling in nociceptors without altering it in the rest of the body, we will determine how testosterone influences inflammation and tissue repair in colitis. The results will advance the understanding of how sex hormones impact disease activity in IBD, potentially explain sex-dependent outcomes and inform therapeutic strategies.

Abstract or Project Description

The epithelial cells lining the intestine control responses to gut bacteria, limiting intestinal damage in Crohn’s disease. A critical gene in this pathway is DUOX2, which is up-regulated in response to bacteria and helps maintain intestinal health. We discovered that Crohn’s disease patients who carry genetic variants in DUOX2 are more likely to progress to fibrotic disease complications requiring surgery. We tested an intestinal gene signature for refractory pediatric Crohn’s disease in a database containing 2000 small molecules, identifying 140 which might be more effective therapies. Our studies will now utilize a novel Human Intestinal Organoid, or “mini-gut” model system for refractory pediatric Crohn’s disease that we have developed informed by genetic factors like DUOX2. We have prepared stem cells from pediatric Crohn’s disease patients who did or did not have DUOX2 genetic variants, and will differentiate them into white blood cells and human intestinal organoids. This novel model system will be used to test ways to modulate pathways linked to fibrosis in patients, by screening the top small molecules which we have identified as potentially beneficial. Our studies will advance precision medicine, by developing a platform to screen new therapies in patient-derived intestinal organoids with clinically important genetic variants.

Abstract or Project Description

To support trainee travel for conferences and professional development in IBD research associated with Dr. Lee Denson’s project.

Abstract or Project Description

Operating under the belief that filmmakers are essential to our culture, Cinemama is fostering connectivity, building a culture and furthering the pro-filmmaker movement in the Bay Area.

Abstract or Project Description

Instigated by Keith Hennessy in 2001, Circo Zero makes live performances responding to political crises, while centering queer bodies and ideas. Producing in unceded Ramaytush Ohlone territory/San Francisco, the broader Bay Area and on tour since 1982, their performances are interdisciplinary and experimental, motivated by anti-racist and decolonial practices.

Abstract or Project Description

“Figure it out (a temporary commune)” is a two-month community residency for creative experiments, workshops and performances taking place October-November 2025 at Space 124. Directed by Circo Zero, “Figure it out” creates a context for queer, cross-racial and intergenerational collaboration centering politically-engaged dance.

Abstract or Project Description

Hip-hop theater ensemble Felonious explores commodification, ageism and survival, as told through the eyes of an almost washed-up band in this new play.

Abstract or Project Description

To support the City of Oakland Cultural Funding Program, the Oakland Arts Pooled Fund, which will restore critical funding for 25 Oakland-based arts and culture organizations whose City of Oakland grants were cut by nearly 80% due to the 2024 budget deficit. Held at the East Bay Community Foundation, the fund will make these organizations whole for their 2025 awards.

Abstract or Project Description

Abstract or Project Description

To support trainee travel for conferences and professional development in IBD research associated with Dr. Hyun Jung Kim’s project.

Abstract or Project Description

The Color of Gastrointestinal Illnesses (COGI) Equity in GI conference focuses on addressing health disparities in gastroenterology for Black and Brown patients. Topics include patient advocacy, provider perspectives and access to care.

Abstract or Project Description

Community Vision is a community development financial institution that has invested more than $607 million in financing and $39 million in grants to support nonprofits and small businesses in disinvested communities. Through grants, flexible capital and real estate and financial advising, Community Vision helps Black, Indigenous and People of Color led arts and community organizations curb displacement and secure permanent cultural spaces.

Abstract or Project Description

CONNI MCKENZIE is a multidisciplinary artist and producer working across dance, theater, video production, mixed media and photography. Her work explores embodied experience, environmental connection and the social histories embedded in place.

Abstract or Project Description

To support trainee travel for conferences and professional development in IBD research associated with Dr. Ilana Brito’s project.

Abstract or Project Description

Council on Foundations (COF) supports over 900 member organizations in the United States and around the world to build trust in philanthropy, expand pathways to giving, engage broader perspectives, and co-create solutions that will lead to a better future for all.

Abstract or Project Description

CounterPulse is a dynamic movement of experimental art that sparks personal transformation and builds enduring community. They provide space and resources for emerging artists and cultural innovators, serving as an incubator for the creation of socially relevant, community-based art and culture.

Abstract or Project Description

CubaCaribe’s mission is to preserve, promote and present the vibrant cultural and artistic traditions of the Caribbean and its Diaspora.

Abstract or Project Description

Oakland-based Cut Fruit Collective will use development funds to instigate a research and development process investigating the heritage and histories of Oakland’s multicultural and multigenerational Asian American and Pacific Islander immigrant community. Centering music as a connecting medium, the project aims to reimagine temporary public art as a participatory act of cultural memory, healing and intergenerational exchange.